Koyo Glucosamine synthesizes protein collagen and proteogliycan in human body strongly stimulate cartilage cells. It constantly repairs the frayed and eroded cartilage and soft tissue. At the same time, it can be the basic components of collagen and proteoglycan. Koyo Glucosamine can restore normal physiological function and operational function of the joints and soft tissue.

 
2. Supplementary function：

Koyo Glucosamine is a catalyst and supplement for joints synovial fluid. By continuously lubricates the articular cartilage surface, it reduces friction and allow the joints to move more flexible. Meanwhile articular synovial fluid is the nutrients carrier to provide adequate nutrition to the articular cartilage.

 
3. Clearance function:

Koyo Glucosamine can remove the harmful enzymes and various harmful factors in the articular space (such as rheumatoid factor, Immune complexes, uric acid, etc.). It eliminates the factors which may causes arthritis and also promotes the synthesis of immunization substances so that the immunity of joints and articular will increase.

 
4. Combat inflammation function：

Inflammation is a complex pathological phenomenon, there are four symptoms on the affected area; reddish, swelling, heat and pain. The most important inflammation symptom is when white blood cells permeate out from blood vessels. When it permeates, it relies on the adhesion molecules on the white blood cells surface and stick on the vascular endothelium. Subsequently, the white blood cells, which are stick on the endothelium, will move slowly. At the connection area of endothelial cells, the cells will deform and permeate through the membrane and reach out of the blood vessel. The white blood cells will accumulated at the inflammation area and gobble up the invasive microorganisms and decomposition of microorganism. At the same time, it will release active oxygen and various enzymes particles to degrade, damage the microorganism. However, the activate oxygen, enzymes particles and decomposition of microorganism are also harmful to human body and cause more serious inflammation.

 
5. Inhibit function:

For rheumatoid arthritis; it does not need white blood cell permeation because it is an aseptic inflammation. The inflammation will be more serious if large numbers of white blood cells permeate out. As referred to the figure, Koyo Glucosamine can inhibits the neutrophil function of white blood cells, thereby preventing inflammation caused by tissue injury, and play an indirect role in the anti-inflammatory.


Japan Nagamachi Gong and other scholars have conducted various experimental researches on the effect of Glucosamine (Koyo Glucosamine) to the neutrophil function of white blood cells. Results are shown in the figures.

In addition, inflammation may produce prostaglandin. Prostaglandin has obvious effect on expanding the blood vessels and causes reddish and heat on the affected area. It can also increase the permeability of blood vascular, strengthen the composition and lower down the edema. It will also cause pain and body heat. Koyo Glucosamine can combat inflammatory as it inhibits the formation of prostaglandin E2.（Please refer to figure）

It successfully makes a breakthrough of the conventional medicine, which can only alleviate the symptoms but not fundamentally treat the main cause of arthritis. It solves the knotty problem of arthritis from the fundamental base.

“At present, Glucosamine (Koyo Glucosamine) is the most direct restoration agent to cartilage in world wide. The medical profession recognizes it as the only specific drugs, which can fundamentally cure the bone and joint diseases.”